Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy.

Frontiers in immunology·2023
Same author

Achieving efficient methane production from protein-rich organic waste in anaerobic digestion: Using conductive materials or regulating inoculum-to-substrate ratios?

Bioresource technology·2023
Same author

Upregulated TNF-α and lactate following ERK-SGK1 activation in the spinal dorsal horn underlies chronic postsurgical pain.

The Chinese journal of physiology·2023
Same author

HNRNPA2B1-mediated m<sup>6</sup>A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.

Journal of translational medicine·2023
Same author

Polyphenol-Based Nanosystems for Next-Generation Cancer Therapy: Multifunctionality, Design, and Challenges.

Macromolecular bioscience·2023
Same author

Advances in Integration, Wearable Applications, and Artificial Intelligence of Biomedical Microfluidics Systems.

Micromachines·2023

Related Experiment Video

Updated: May 3, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

9.3K

Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials.

RangRang Fan1, XiaoHui Deng2, LiangXue Zhou1

  • 1State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.

International Journal of Nanomedicine
|February 4, 2014
PubMed
Summary

Researchers developed injectable hydrogels using modified calcium phosphates (g-β-TCP and g-TTCP) within a thermosensitive polymer matrix (PECE). These novel materials show potential for controlled calcium release and tissue engineering applications.

Keywords:
biocompatibilitycalcium phosphateinjectablesurface functionalizationthermosensitivity

More Related Videos

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.4K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.2K

Related Experiment Videos

Last Updated: May 3, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

9.3K
Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.4K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.2K

Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Tissue Engineering

Background:

  • Calcium phosphates like beta-tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) are crucial in bone regeneration.
  • Developing injectable and thermosensitive delivery systems for these materials is essential for advanced tissue engineering.

Purpose of the Study:

  • To create functionalized poly(l-lactic acid)-grafted calcium phosphates (g-β-TCP and g-TTCP).
  • To incorporate these modified particles into a polyethylene glycol-polycaprolactone-polyethylene glycol (PEG-PCL-PEG or PECE) matrix to form injectable thermosensitive hydrogel composites.
  • To evaluate the properties and potential of these hydrogel composites for controlled calcium release and tissue engineering.

Main Methods:

  • Surface modification of β-TCP and TTCP with L-lactide to form PLLA-grafted particles (g-β-TCP, g-TTCP).
  • Incorporation of g-β-TCP and g-TTCP into a PECE polymer matrix to create injectable hydrogel composites.
  • Morphological analysis using microscopy to assess particle dispersion and network structure.
  • Rheological analysis to evaluate thermosensitive properties.
  • In vitro assessment of calcium release and pH changes in simulated body fluid.

Main Results:

  • Homogeneous dispersion of g-β-TCP and g-TTCP particles within the PECE matrix, forming a 3D network structure.
  • Demonstrated good thermosensitivity of the hydrogel composites.
  • Confirmed controlled release of calcium ions and pH modulation in simulated body fluid, validating surface functionalization.
  • The developed hydrogels exhibited characteristics suitable for biomedical applications.

Conclusions:

  • Surface-functionalized calcium phosphate particles (g-β-TCP and g-TTCP) can be successfully incorporated into injectable thermosensitive PECE hydrogels.
  • These hydrogel composites exhibit desirable properties for controlled calcium release.
  • The g-β-TCP/PECE and g-TTCP/PECE hydrogels represent a promising approach for future tissue engineering strategies.