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Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese
Ying Zhao1, Yanbo Yu2, Xiaoli Tian3
1Department of Geriatrics, Jinan Military General Hospital, Jinan, China.
Insights
Genetic variations in FoxO1 and FoxO3 do not appear to increase the risk of coronary heart disease (CHD) in the Han Chinese population. This study investigated these genetic factors in relation to CHD prevalence.
Area of Science:
- Genetics
- Cardiovascular Disease Research
- Population Health
Background:
- Coronary heart disease (CHD) is a significant cause of mortality in China.
- The genetic underpinnings of CHD susceptibility remain largely undefined.
- Forkhead box proteins (FoxOs) are implicated in longevity and may influence disease risk.
Purpose of the Study:
- To investigate the association between variations in FoxO1 and FoxO3 genes and CHD in Han Chinese individuals.
- To determine if specific single nucleotide polymorphisms (SNPs) in FoxO1 and FoxO3 are risk factors for CHD.
Main Methods:
- A case-control study involving 1271 CHD patients and 1287 controls from Beijing and Harbin.
- Genotyping of six tagging SNPs: four in FoxO1 (rs2755209, rs2721072, rs4325427, rs17592371) and two in FoxO3 (rs768023, rs1268165).
- Stratified analyses were performed based on gender, smoking history, hypertension, diabetes, hyperlipidemia, and metabolic syndrome.
Main Results:
- No significant association was found between the selected FoxO1 and FoxO3 SNPs and CHD in the Beijing population (p>0.05).
- These findings were consistent in the Harbin population, confirming the lack of association (p>0.05).
- Combined analysis and stratified analyses across various risk factors also revealed no significant link between FoxO1/FoxO3 variants and CHD in the Han Chinese population.
Conclusions:
- The studied variants of FoxO1 and FoxO3 genes do not appear to be associated with an increased prevalence of coronary heart disease in the Han Chinese population.
- These genetic factors may not play a significant role in the predisposition to CHD within this demographic group.
Background:
Coronary heart disease (CHD) is one of the leading causes of mortality and morbidity in China. Genetic factors that predispose individuals to CHD are unclear. In the present study, we aimed to determine whether the variation of FoxOs, a novel genetic factor associated with longevity, was associated with CHD in Han Chinese populations.
Methods:
1271 CHD patients and 1287 age-and sex-matched controls from Beijing and Harbin were included. We selected four tagging single nucleotide polymorphisms (SNPs) of FoxO1 (rs2755209, rs2721072, rs4325427 and rs17592371) and two tagging SNPs of FoxO3 (rs768023 and rs1268165). And the genotypes of these SNPs were determined in both CHD patients and non-CHD controls.
Results:
For population from Beijing, four SNPs of FoxO1 and two SNPs of FoxO3 were found not to be associated with CHD (p>0.05). And this was validated in the other population from Harbin (p>0.05). After combining the two geographically isolated case-control populations, the results showed that the six SNPs did not necessarily predispose to CHD in Han Chinese(p>0.05). In stratified analysis according to gender, the history of smoking, hypertension, diabetes mellitus, hyperlipidemia and the metabolic syndrome, we further explored that neither the variants of FoxO1 nor the variants of FoxO3 might be associated with CHD (p>0.05).
Conclusion:
The variants of FoxO1 and FoxO3 may not increase the prevalence of CHD in Han Chinese population.
