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Updated: May 3, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Acute-on-chronic liver failure (ACLF)--a new entity in hepatology?]
Ivana Mikolasević1, Mladen Radić2, Sandra Milić2
1Zavod za gastroenterologiju, Klinika za internu medicinu, Medicinski fakultet Sveucilista u Rijeci, Klinicki bolnicki center Rijeka. ivana.mikolasevic@yahoo.com
Abstract:
Recently, acute-on-chronic liver failure has been recognized as a specific and unique clinical form of liver failure (usually related to acute insult) in patients with previously known or unknown compensated chronic liver disease. Its main feature is the reversibility, and high short-mortality due to multiorgan failure (MOF) in the absence of liver support system devices and/or liver transplantation. This article aims to introduce the definition and better understanding of this newly developed and unique profile of liver failure.
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