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[Effect of paclitaxel on platelet aggregation induced by adenosine diphosphate in vitro]
Shu Zhang1, Chang-Li Sun1, Hu Nie1
1Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the effect of paclitaxel on platelet aggregation induced by adenosine diphosphate (ADP) in vitro.
Methods:
Platelet suspension was incubated with paclitaxel in different concentrations (0 ng/mL, 0.01 ng/mL, 0.1 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL, 1 000 ng/mL), then the maximal extent of platelet aggregation was determined under the conditions of the best ADP concentration and the best incubation time.
Results:
Under the condition of 10 micromol/L ADP and incubated for 10 min, with the increase of paclitaxel concentration, the effect of paclitaxel on platelet aggregation induced by ADP elevated accordingly, and the differences among the different concentration groups were statistically significant (P < 0.05).
Conclusion:
Paclitaxel can enhance ADP-induced platelet aggregation in a concentration-dependent manner in vitro.
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