[Blood lipid, glucose and uric acid in people with subclinical hypothyroidism]
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Li-Bo Liang1, Mei Zhang2, Heng-Jian Huang2
1Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism.
Methods:
Body mass index (BMI), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and uric acid (UA) were measured and compared in 356 people with subclinical hypothyroidism and 331 health people (controls).
Results:
Compared to the control group, people with subclinical hypothyroidism had higher levels of BMI, TSH, TC, LDL-C, TG, FBG, UA (P < 0.05) and non-significant decrease of HDL-C (P > 0.05). The level of TSH was positively correlated with TC (r = 0.254), LDL-C (r = 0.110), TG (r = 0.218), BMI (r = 0.119) and FBG (r = 0.210) (P < 0.05). The level of HDL-C was not correlated with TSH (P > 0.05).
Conclusion:
Thyroid dysfunction may have an effect on the metabolism of blood lipid, FBG and UA.
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