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Published on: November 4, 2022
[Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets]
Yan-Qu Cai1, Zhi-Peng Zhang2, Yan-Hong Wu3
1Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China. ayu19860524@163.com
Objective:
To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.
Method:
The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.
Result:
The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.572 5f-20. 729 (R2 = 0.974 5); F(pseudoephedrine) = 1.237f-0.147 6 (R2 = 0.959 5).
Conclusion:
The results suggested that there was fine correlation between the absorption percentage in vivo and the accumulative release percentage in vitro of Chuanping sustained release tablets.
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