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Updated: May 3, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
Mitochondrial production of reactive oxygen species
V G Grivennikova1, A D Vinogradov
1Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, Moscow, 119991, Russia. vgrivennikova@mail.ru.
Abstract:
Numerous biochemical studies are aimed at elucidating the sources and mechanisms of formation of reactive oxygen species (ROS) because they are involved in cellular, organ-, and tissue-specific physiology. Mitochondria along with other cellular organelles of eukaryotes contribute significantly to ROS formation and utilization. This review is a critical account of the mitochondrial ROS production and methods for their registration. The physiological and pathophysiological significance of the mitochondrially produced ROS are discussed.
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