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Primary gastric lymphoma. Problems in staging and management
R E Jones1, S Willis, D J Innes
1Department of Surgery, University of Virginia Medical Center, Charlottesville.
American Journal of Surgery
|January 1, 1988
Summary
Optimal treatment for primary gastric lymphoma remains crucial. Surgical resection offers survival benefits, with curative resection yielding better outcomes than palliative, especially when combined with adjuvant therapies for advanced stages.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Hematology
Background:
- Primary gastric lymphoma often presents with symptoms mimicking peptic ulcer disease or gastric carcinoma.
- The diffuse histiocytic subtype was the most common histological finding in this patient cohort.
Purpose of the Study:
- To determine the optimal treatment modality for primary gastric lymphoma.
- To evaluate the impact of surgical resection and adjuvant therapies on patient survival.
Main Methods:
- A retrospective review of 28 patients diagnosed with primary gastric lymphoma.
- Analysis of treatment modalities, including surgical resection (palliative vs. curative), and staging.
Main Results:
- A 75% resectability rate was observed in surgically treated patients.
- Five-year survival rates were 28% for palliative resection and 43% for curative resection.
- Stage IB disease showed a median survival of 32 months, contrasting with 8 months for stage III disease.
Conclusions:
- Surgical resection is a key treatment for primary gastric lymphoma, with curative intent offering superior survival.
- Adjuvant radiotherapy and chemotherapy may enhance survival in cases with serosal penetration or nodal involvement following curative resection.