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Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Evaluation of alternative rapid thin layer chromatography systems for quality control of technetium-99m
Kennedy Mang'era1, Derek Wong2, David Douglas3
1Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9,; Radiology, Faculty of Medicine, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, Canada R3T 2N2; Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5.
Abstract:
Whatman 3MM™ and Tec-Control™ systems were evaluated as ITLC-SG alternatives for 99mTc-radiopharmaceuticals. They compare well in accuracy and reproducibility, and are faster and more convenient than ITLC-SG. Tec-Control™ radiochemical purity values for 99mTc-sestamibi were more conservative than ITLC-SG. Full solvent migration was not reproduced for 99mTc-tetrofosmin in Tec-Control™, and for this Whatman 3MM™ is preferred. Developing times were 10-15 min, 7-9 min and ~1min for ITLC-SG, Whatman 3MM™ and Tec-Control™, respectively. Overall, Tec-Control™ strips are preferred due to speed and ease of use.
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