Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

5.4K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
7.5K
Regulation of Heart Rates01:31

Regulation of Heart Rates

6.0K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
6.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of metabolic rewiring in MDR1-overexpressing drug-resistant glioblastoma.

Frontiers in pharmacology·2026
Same author

Multi-Environment Evaluation and Stability Analysis for the Selection of Elite Pearl Millet Genotypes with Better Fodder Yield and Quality Component Traits.

Plants (Basel, Switzerland)·2026
Same author

Enhancing hybridization potential through standardizing emasculation techniques and molecular marker integration in finger millet (Eleusine coracana L.).

Plant methods·2026
Same author

Evolutionary-guided advanced deep-learning architecture powers mammalian GPCRome agonist predictions.

Cell reports·2026
Same author

Purification of human sperm-specific PGK2 and assay development for drug screening for potential non-hormonal contraceptives.

Biochimica et biophysica acta. Proteins and proteomics·2026
Same author

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR-Gα interface.

eLife·2025
Same journal

Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology.

Ageing research reviews·2026
Same journal

Macrophage Senescence and Programmed Cell Death in Atherosclerosis: Mechanisms, Cross-Talk, and Emerging Therapeutic Strategies.

Ageing research reviews·2026
Same journal

Amylin at the crossroads of type 2 diabetes and neurodegenerative diseases.

Ageing research reviews·2026
Same journal

Cell death regulation: A novel way of natural products to treat myocardial hypertrophy.

Ageing research reviews·2026
Same journal

Digital technologies for healthy longevity: A policy agenda from the Einstein circle on inclusive, data-driven ageing societies.

Ageing research reviews·2026
Same journal

Molecular and environmental drivers of tau post-translational modifications and tau pathology.

Ageing research reviews·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.2K

Non-coding RNAs in cardiovascular ageing.

Shashi Kumar Gupta1, Maria Teresa Piccoli1, Thomas Thum2

  • 1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany.

Ageing Research Reviews
|February 5, 2014
PubMed
Summary
This summary is machine-generated.

Ageing populations present healthcare challenges. MicroRNAs and long noncoding RNAs (lncRNAs) are key regulators of ageing, particularly cardiovascular ageing, offering new research avenues.

Keywords:
AgeingCardiovascularMicroRNAslncRNAs

More Related Videos

Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling
09:12

Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling

Published on: January 23, 2026

3.1K
Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

1.7K

Related Experiment Videos

Last Updated: May 3, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.2K
Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling
09:12

Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling

Published on: January 23, 2026

3.1K
Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

1.7K

Area of Science:

  • Gerontology and Molecular Biology
  • Focus on non-coding RNA's role in cellular ageing.

Background:

  • Global ageing populations increase healthcare burdens.
  • Ageing is a complex disorder involving progressive functional decline and increased disease incidence.
  • MicroRNAs (non-coding RNAs) regulate gene expression and are implicated in ageing.

Purpose of the Study:

  • To summarize the role of microRNAs and long noncoding RNAs (lncRNAs) in ageing.
  • To emphasize the specific involvement of these non-coding RNAs in cardiovascular ageing.

Main Methods:

  • Literature review of studies on microRNAs and ageing.
  • Analysis of research on long noncoding RNAs (lncRNAs) in the ageing process.
  • Focus on studies investigating non-coding RNA regulation in cardiovascular ageing.

Main Results:

  • MicroRNAs are critical regulators of ageing across species.
  • Specific microRNAs, such as miR-34, are identified as key ageing regulators.
  • Long noncoding RNAs (lncRNAs) also play a significant role in ageing.

Conclusions:

  • MicroRNAs and lncRNAs are integral to the ageing process.
  • These non-coding RNAs, especially in the context of cardiovascular ageing, represent important therapeutic and research targets.