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Updated: Jan 26, 2026

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
Published on: December 13, 2024
Ca-dependent ADPase--the possible regulator of calcium channel during the deficiency of ATP
1Institute of Experimental Surgery, Slovak Academy of Sciences, Bratislava.
Abstract:
Activation of the low affinity Ca-ATPase and Ca-ADPase by increasing concentrations of their cationic cofactor calcium (0.1-8.0 mmol.l-1) or by increasing concentration of substrates ATP or ADP (0.1-8.0 mmol.l-1) was influenced on similar mode by sodium azide. Kinetic analysis of the NaN3 induced inhibition, revealed that both enzyme activities are probably secured by the same system which is capable to hydrolyze ADP during the absence of ATP. A possible role for Ca-ADPase in controlling the calcium channel during ATP deficiency is discussed.
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