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Decreased contractile response after exposure of the rat aorta to Db cAMP or IBMX
1Central Institute of Cardiovascular Research, Academy of the Sciences of the GDR, Berlin-Buch.
Biomedica Biochimica Acta
|January 1, 1987
Abstract:
Isometric tension developed by different receptor agonists was found to be decreased after pretreatment of rat aortic rings with IBMX or Db cAMP and only partially restored by CaCl2 and A 23187. The contraction produced by Bay k 8644 was converted into dose-dependent relaxation after pretreatment of the aorta rings with Db cAMP or IBMX. An alteration of the calcium channel is assumed to play a common role in the cAMP-dependent inhibition of the smooth muscle contraction.