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Updated: May 3, 2026

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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Cellular reprogramming.

Kazutoshi Takahashi1

  • 1Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan.

Cold Spring Harbor Perspectives in Biology
|February 5, 2014
PubMed
Summary

Nuclear reprogramming rejuvenates cells by resetting epigenetic memory. This breakthrough enables patient-specific induced pluripotent stem cells for disease research and regenerative medicine.

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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