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Dynamically reconfigurable fibre optical spanner.

Thorsten Kolb1, Sahradha Albert, Michael Haug

  • 1Biophysics Group, Department of Physics, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestrasse 91, 91052 Erlangen, Germany. gwhyte@biomed.uni-erlangen.de.

Lab on a Chip
|February 5, 2014
PubMed
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We developed a novel fiber-optic spanner on a microfluidic chip to trap and rotate living cells. This system enables tomographic imaging and reveals sub-cellular composition through rotation patterns.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Optical Tweezers

Background:

  • Controlled manipulation of living cells is crucial for biological studies.
  • Existing methods for cell rotation often lack precision or multi-planar capabilities.

Purpose of the Study:

  • To introduce a pneumatically actuated fiber-optic spanner integrated into a microfluidic Lab-on-a-Chip device.
  • To enable controlled trapping and rotation of living cells in multiple planes for advanced imaging.
  • To demonstrate the potential for analyzing sub-cellular composition based on cell rotation dynamics.

Main Methods:

  • Integration of a pneumatically actuated fiber-optic spanner within a microfluidic Lab-on-a-Chip device.
  • Utilizing multi-layer device architecture for both in-plane and perpendicular cell rotation.

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  • Combining the device with high-resolution confocal microscopy for detailed observation.

    • Main Results:

    • Demonstrated dynamic and interactive control over cell rotation speed.
    • Achieved multi-planar rotation, enabling tomographic imaging of trapped cells.
    • Established a correlation between cell rotation patterns and sub-cellular composition.

    Conclusions:

    • The integrated fiber-optic spanner offers a novel and effective tool for precise cell manipulation.
    • Multi-planar rotation and subsequent imaging provide new insights into cell structure.
    • Rotation pattern analysis presents a promising method for non-invasive sub-cellular analysis.