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Meta-analysis of the cytotoxic T-lymphocyte antigen 4 gene +6230G/A polymorphism and cancer risk

H-Y Zhao1, H-X Duan, Y Gu

  • 1Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, 210003, China, zhaohy1223@163.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|February 5, 2014
PubMed
Abstract

Insights

The CTLA-4 +6230G/A polymorphism is linked to a reduced risk of breast and cervical cancers. This genetic variation may influence cancer susceptibility, particularly in Asian populations.

Area of Science:

  • Immunogenetics
  • Cancer Epidemiology
  • Molecular Biology

Background:

  • Cytotoxic T-lymphocyte antigen-4 (CTLA4) is a key immunosuppressive molecule inhibiting T-cell activation.
  • The CTLA-4 +6230G/A polymorphism has been investigated for its association with various cancer risks.
  • Previous studies yielded controversial results regarding this genetic polymorphism and cancer susceptibility.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between CTLA-4 +6230G/A polymorphism and cancer risk.
  • To provide a more precise estimation of the relationship by synthesizing existing evidence.
  • To explore potential associations stratified by cancer type and ethnicity.

Main Methods:

  • A comprehensive literature search was performed in the PubMed database up to November 21, 2013.
  • A meta-analysis was conducted using data from 13 articles (14 studies) involving 4,489 cancer cases and 4,715 controls.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations.

Main Results:

  • Overall analysis showed no significant association between CTLA-4 +6230G/A polymorphism and general cancer risk.
  • Stratified analysis revealed a significant association with decreased risk for breast cancer (e.g., AA vs. GG: OR=0.66, P=0.02) and cervical cancer (AA vs. AG+GG: OR=0.56, P<0.01).
  • Subgroup analysis by ethnicity indicated a significant association with reduced cancer risk in the Asian population (AA vs. AG+GG: OR=0.71, P<0.01).

Conclusions:

  • The CTLA-4 +6230G/A polymorphism may be associated with a decreased risk of breast and cervical cancers.
  • This association appears particularly relevant in the Asian population.
  • Further research may elucidate the precise mechanisms underlying this genetic influence on cancer risk.

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