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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
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Related Experiment Video

Updated: May 3, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
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Methods for gene transfer to synovium.

R Kang1, P D Robbins, C H Evans

  • 1Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Methods in Molecular Medicine
|February 5, 2014
PubMed
Summary
This summary is machine-generated.

Gene therapy offers a promising approach for treating rheumatoid arthritis (RA) by enabling targeted gene transfer to synoviocytes. This method aims to overcome the limitations of current systemic drug delivery for joint disorders.

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Area of Science:

  • Biotechnology
  • Gene Therapy
  • Rheumatology

Background:

  • Current treatments for rheumatoid arthritis (RA) and other joint disorders face challenges with drug targeting and efficacy.
  • Traditional drug delivery methods require high systemic concentrations, leading to potential side effects and compromised joint perfusion.
  • Chronic RA necessitates long-term, high-dose medication, exacerbating safety concerns.

Purpose of the Study:

  • To explore the development of gene transfer methods for synoviocytes.
  • To investigate gene therapy as a potential strategy for improved treatment of RA and joint disorders.

Main Methods:

  • Focus on the development of novel gene transfer techniques.
  • Targeting gene delivery to synoviocytes within the joint.

Main Results:

  • The study explores the foundational concept of gene transfer to synoviocytes.
  • Highlights the potential for gene therapy to address limitations in current RA treatments.

Conclusions:

  • Gene therapy holds promise for more effective and targeted treatment of rheumatoid arthritis.
  • Developing gene transfer methods for synoviocytes could revolutionize joint disorder management.