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Updated: May 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Dimensions of Temperament and Depressive Symptoms: Replicating a Three-Way Interaction
Michael W Vasey1, Casaundra N Harbaugh1, Chistopher J Lonigan2
1The Ohio State University, 1835 Neil Ave., Columbus, OH 43210.
Abstract:
High negative emotionality (NE), low positive emotionality (PE), and low self-regulatory capacity (i.e., effortful control or EC) are related to depressive symptoms and furthermore, may moderate one another's relations to such symptoms. Indeed, preliminary evidence suggests they may operate in a three-way interaction (Dinovo & Vasey, 2011), but the replicability of that finding remains unknown. Therefore, we tested this NExPExEC interaction in association with depressive symptoms in 5 independent samples. This interaction was significant in 4 of the 5 samples and a combined sample and approached significance in the fifth sample. In contrast, the NExPExEC interaction was unrelated to general anxious symptoms and thus may be specific to symptoms of depression. Implications, directions for future research, and limitations are discussed.
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