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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Related Experiment Video

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Vitamin D and melanoma.

Sinead Field1, John Davies1, D Tim Bishop1

  • 1Section of Epidemiology and Biostatistics; University of Leeds; Leeds, UK.

Dermato-Endocrinology
|February 5, 2014
PubMed
Summary

Individuals genetically susceptible to melanoma and sensitive to sun exposure often have low vitamin D levels. Supplementation is recommended for these sun-avoidant individuals to prevent vitamin D insufficiency and potentially improve melanoma prognosis.

Keywords:
25-hydroxyvitamin D2/D3 levelspreventionrisksupplementationsurvivalvitamin D serum levels

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Area of Science:

  • Dermatology
  • Endocrinology
  • Nutritional Science

Background:

  • Recreational sun exposure and sunburn are established causes of melanoma.
  • Melanoma risk is significantly influenced by genetic factors, particularly in individuals with specific phenotypic traits.

Purpose of the Study:

  • To examine the relationship between sun sensitivity, vitamin D levels, and melanoma risk.
  • To evaluate the efficacy of vitamin D supplementation for melanoma-prone individuals.
  • To investigate the association between vitamin D levels and melanoma tumor characteristics and prognosis.

Main Methods:

  • Review of evidence linking sun sensitivity to lower vitamin D levels.
  • Discussion of challenges in achieving sufficient vitamin D without supplementation in sun-avoidant populations.
  • Observational study of serum 25-hydroxyvitamin D2/D3 levels in a melanoma cohort at diagnosis and post-diagnosis.

Main Results:

  • Sun-sensitive individuals often exhibit lower vitamin D levels, making supplementation necessary in regions like the UK.
  • Preliminary findings suggest lower vitamin D levels at diagnosis correlate with thicker melanoma tumors and poorer prognosis.
  • Melanoma patients in the UK frequently present with suboptimal vitamin D levels.

Conclusions:

  • Melanoma-susceptible, sun-avoidant individuals should be advised to supplement with vitamin D to avoid insufficiency.
  • Vitamin D may possess anti-proliferative properties against melanoma cells in vitro.
  • Further research and management strategies are needed for melanoma patients with vitamin D deficiency.