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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Pyelonephritis
1University of the West of England.
Insights
Acute pyelonephritis, a kidney infection, affects approximately 1 in 830 UK individuals annually. This serious urinary tract infection is notably more common in females than males.
Area of Science:
- Nephrology
- Urology
- Infectious Diseases
Background:
- Acute pyelonephritis is a severe upper urinary tract infection originating from a lower urinary tract infection that ascends to the renal pelvis.
- Kidney infections represent a significant public health concern, with notable demographic variations in incidence.
Purpose of the Study:
- To define acute pyelonephritis and its epidemiological characteristics.
- To highlight the prevalence and sex-based incidence disparities of kidney infections in the UK population.
Main Methods:
- Literature review and epidemiological data analysis.
- Synthesis of existing research on urinary tract infections and kidney infections.
Main Results:
- Acute pyelonephritis involves the kidney's pelvis, stemming from a lower urinary tract infection.
- An estimated 1 in 830 individuals in the UK are affected by kidney infections annually.
- Females exhibit a sixfold higher likelihood of experiencing kidney infections compared to males.
Conclusions:
- Acute pyelonephritis is a prevalent condition, particularly in females.
- Understanding the epidemiology of kidney infections is crucial for targeted prevention and treatment strategies.
- Further research into the underlying causes of sex-based disparities in acute pyelonephritis is warranted.
Abstract:
Acute pyelonephritis refers to a lower urinary tract infection that has spread to the pelvis of the kidney. An estimated one in 830 people in the UK experience kidney infection every year, and females are six times more likely to experience the infection than males.
Related Concept Videos
Acute Pyelonephritis I: Introduction
Acute Pyelonephritis II: Diagnostic Studies and Management
Urinary Tract Infection II: Pathophysiology
Nephrons
Acute Kidney Injury II: Pathophysiology
Urinary Tract Infection I: Introduction

