Related Experiment Video
Updated: May 3, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[A woman with needle-shaped crystals in the urine]
Martijn Boon1, Joost van de Ven, G C Trudy van Melsen
1Leids Universitair Medisch Centrum, afd. Anesthesiologie, Leiden.
Abstract:
A 24-year-old female patient was admitted to the ICU with suspected meningo-encephalitis. She was treated with antibiotics and acyclovir 1500 mg/day. Forty-eight hours later she developed acute renal failure with needle-shaped crystals in the urine. Acyclovir treatment was suspended and renal function replacement therapy was initiated. After two weeks, her renal function had fully recovered. Based on the typical clinical course and the typical crystalluria, we diagnosed her with acyclovir-induced acute renal failure.
More Related Videos
08:53Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
Published on: December 4, 2020
09:01Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification
Published on: September 15, 2012
Related Concept Videos
Urine Studies I: Urinalysis
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Formation of Concentrated Urine
Formation of Dilute Urine
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
Urine Studies II: Urine Culture and Sensitivity Test
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care