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Updated: May 3, 2026
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices
Kuniaki Nagamine1, Kohei Okamoto2, Hirokazu Kaji1
1Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan; JST-CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
Abstract:
We show the fibrous protein fibrin can serve as biocompatible glue with which to bind synthetic cationic or anionic hydrogels together. Both the bonding to and detachment from the hydrogels by fibrin (gelation and degradation, respectively) proceeded enzymatically under physiological conditions. We built a hydrogel-based actuator to demonstrate the method.
