Related Experiment Video
Updated: May 3, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Catalytic regioselective synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones and their biological evaluation
Shailesh P Satasia1, Piyush N Kalaria, Dipak K Raval
1Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar-388 120, Gujarat, India. dipanalka@yahoo.com.
Abstract:
A new type of biopolymer-based heterogeneous catalyst, cellulose supported acidic ionic liquid (Cell-IL), which was developed earlier in our lab, has been found to be very effective for the regioselective synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones. Its regioselectivity was confirmed by (1)H NMR spectroscopy. All the newly synthesized compounds were characterized by LC-MS, (1)H NMR, (13)C NMR, IR spectroscopy and elemental analysis. The newly synthesized compounds were evaluated for their in vitro antimalarial activity against Plasmodium falciparum, in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv strain and also for their antibacterial activity against a panel of pathogenic strains of bacteria and fungi. Some of them exhibited excellent activity when compared with first line drugs.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Regioselectivity of Electrophilic Additions-Peroxide Effect
Basicity of Heterocyclic Aromatic Amines

