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Systemic therapies for psoriasis: an evidence-based update.

Laura F Sandoval1, Allison Pierce, Steven R Feldman

  • 1Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA, lsandova@wakehealth.edu.

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Biologic agents are effective for moderate to severe psoriasis, offering better efficacy and safety than traditional treatments. Newer agents, including anti-interleukin-17 therapies, show promise in ongoing clinical trials.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Trials

Background:

  • Psoriasis treatment has shifted towards biologic agents.
  • Evidence-based studies are crucial for guiding physician decisions with expanding treatment options.

Purpose of the Study:

  • To provide an evidence-based update on systemic therapies for psoriasis.
  • To review current literature on psoriasis treatment efficacy and safety.

Main Methods:

  • Systematic literature review from January 2012 to July 2013.
  • Inclusion of randomized clinical trials and systematic reviews of systemic psoriasis treatments.

Main Results:

  • 46 publications were reviewed, focusing on biologic agents and anti-interleukin-17 (IL-17) agents.
  • Anti-IL-17 agents demonstrated efficacy in Phase II trials. New oral agents show potential as safer alternatives to traditional therapies.
  • Infliximab was superior among tumor necrosis factor-alpha inhibitors, while etanercept was least effective. Biologics show encouraging long-term safety data.

Conclusions:

  • Biologic agents are supported for moderate to severe psoriasis treatment due to superior efficacy and safety compared to traditional systemic agents.
  • Emerging anti-IL-17 agents and new oral therapies show promise in clinical trials.
  • Further research on traditional oral therapies is lacking.