[Invasive breast cancer: the current WHO classification]

Area of Science:

• Pathology
• Oncology
• Genetics

Context:

• The World Health Organization (WHO) classification of breast tumors establishes international standards for tumor categorization and nomenclature.
• The 2012 fourth edition represents a significant update, incorporating current knowledge on classification, immunohistology, differential diagnosis, and genetics of breast lesions.

Purpose:

• To provide an updated overview of the 2012 WHO classification of breast tumors, focusing on invasive carcinomas.
• To detail the modifications from the previous edition, including revised terminology, reclassified entities, and new molecular data.
• To supplement histological diagnostic definitions with clinical, macroscopic, molecular, prognostic, and predictive features.

Summary:

• The 2012 WHO classification of breast tumors updates tumor categorization and nomenclature standards.
• This article specifically addresses invasive carcinomas, integrating clinical, macroscopic, and molecular characteristics.
• Key updates include modified terms, reclassified entities, and the incorporation of current molecular data and prognostic/predictive features.

Impact:

• Facilitates standardized and accurate diagnosis of breast tumors globally.
• Enhances understanding of invasive breast carcinomas by integrating diverse diagnostic parameters.
• Supports improved patient management through comprehensive prognostic and predictive information.