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Isovolemic hemodilution in stroke. A study in gerbils.
J P Kapp1, R R Smith, D F Peeler
1Department of Neurosurgery, State University of New York, Buffalo 14214.
Surgical Neurology
|March 1, 1988
Summary
Isovolemic hemodilution with dextran did not reduce neurological deficits in gerbils after carotid ligation. This procedure significantly increased 24-hour mortality in the experimental group compared to controls.
Area of Science:
- Neurology
- Cardiovascular Science
- Experimental Medicine
Background:
- Isovolemic hemodilution is proposed to enhance cerebral perfusion and treat acute cerebral infarction.
- The efficacy and safety of this procedure in acute ischemic conditions require further investigation.
Purpose of the Study:
- To evaluate the impact of isovolemic hemodilution using low-molecular-weight dextran on mortality and neurological deficits.
- To assess the potential of this intervention in a gerbil model of cerebral infarction.
Main Methods:
- Sixty-four Mongolian gerbils underwent ligation of the left internal carotid artery.
- The experimental group received isovolemic hemodilution with dextran, reducing hematocrit to 30.5%.
- Control animals did not undergo hemodilution; both groups were observed for 24 hours.
Main Results:
- The incidence of neurological deficit was similar between groups (67% control vs. 64% experimental).
- Mortality within 24 hours was significantly higher in the hemodilution group (75%) compared to controls (28%).
Conclusions:
- Isovolemic hemodilution with dextran did not improve neurological outcomes after carotid ligation in gerbils.
- The procedure was associated with a substantial increase in early mortality, questioning its therapeutic value in this model.