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Published on: September 5, 2016
Immune-mediated mechanism for thrombocytopenia after Loxosceles spider bite
Carina Levin1, Lilach Bonstein, Roy Lauterbach
1Pediatric Hematology Unit and Pediatric Department B, Emek Medical Center, Afula, Israel; The Ruth and Baruch Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Abstract:
Loxoscelism, characterized by high fever, vomiting, malaise, a dermonecrotic lesion, and thrombocytopenia, was diagnosed in a 3-year-old female. Clinical laboratory and dermatological signs are described. Blood test showed a transient hypercoagulable state and the presence of IgG antibodies against platelets, suggesting an immune-mediated mechanism for platelet destruction, in addition to the direct toxic effect of the spider venom. The finding of platelet antibodies after a Loxosceles spider bite has not been previously reported.
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