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Related Concept Videos

Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Related Experiment Video

Updated: May 3, 2026

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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Single cell genomics: advances and future perspectives.

Iain C Macaulay1, Thierry Voet2

  • 1Single Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

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|February 6, 2014
PubMed
Summary
This summary is machine-generated.

Single-cell sequencing technologies allow detailed study of genomic and transcriptomic heterogeneity in development and disease. These powerful single-cell approaches reveal unprecedented diversity across an organism's lifetime.

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Area of Science:

  • Genomics
  • Transcriptomics
  • Molecular Biology

Background:

  • Single-cell sequencing advances enable analysis of minute DNA and RNA amounts.
  • Genomic and transcriptomic heterogeneity is crucial in normal development and disease.

Purpose of the Study:

  • To review technological and biological breakthroughs in single-cell sequencing.
  • To outline current challenges and future promise of single-cell approaches.

Main Methods:

  • Whole-genome amplification and sequencing.
  • Whole-transcriptome amplification and sequencing.

Main Results:

  • Single-cell approaches provide insights into genomic and transcriptomic heterogeneity.
  • These methods reveal the scale of diversity throughout an organism's life.

Conclusions:

  • Single-cell technologies are revolutionizing the understanding of biological diversity.
  • Continued development promises deeper insights into epigenomics and transcriptomics.