Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.9K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

3.2K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.2K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex.

The Journal of physiology·2026
Same author

Qualitative EEG abnormalities in ASD reflect inhibition-dominated brain dynamics.

Scientific reports·2026
Same author

Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Dimensionality reduction of quantitative EEG and clinical profiles uncover associations with monogenic neurodevelopmental phenotypes in SNAREopathies.

Frontiers in neuroscience·2026
Same author

Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema.

Neurobiology of disease·2026
Same author

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain
05:28

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Published on: August 9, 2024

1.9K

Competitive dynamics during resource-driven neurite outgrowth.

J J Johannes Hjorth1, Jaap van Pelt1, Huibert D Mansvelder1

  • 1Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands.

Plos One
|February 6, 2014
PubMed
Summary

Neurite outgrowth involves competition for tubulin, a key growth resource. This competition can explain why some branches grow while others retract, shaping neuronal networks.

More Related Videos

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
10:45

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures

Published on: October 14, 2021

4.9K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.3K

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain
05:28

Author Spotlight: Unveiling the Molecular Basis of Pain Perception and Neuropathic Pain

Published on: August 9, 2024

1.9K
In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
10:45

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures

Published on: October 14, 2021

4.9K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.3K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Computational Biology

Background:

  • Neurons form complex networks through neurite outgrowth and synaptogenesis.
  • Neurite branching exhibits competitive dynamics, with outgrowth often coinciding with retraction.
  • The mechanisms driving this neurite competition remain largely unknown.

Purpose of the Study:

  • To investigate if competition for growth resources, specifically tubulin, can explain observed neurite outgrowth dynamics.
  • To model the relationship between tubulin dynamics and competitive neurite branching.

Main Methods:

  • Developed a multi-compartmental model of neurite growth.
  • Modeled tubulin production in the soma and transport (diffusion and active) to neurite growth cones.
  • Simulated tubulin assembly into microtubules for neurite elongation.

Main Results:

  • The model successfully replicated experimental observations of competitive neurite outgrowth and retraction.
  • Competitive interactions were demonstrated in both simple and complex neurite morphologies.
  • Model predictions indicate competition decreases with distance between growth cones and increases with distance from the soma.

Conclusions:

  • Competition for tubulin can account for differential neurite branch outgrowth in developing neurons.
  • Simple dynamics of growth resources can lead to complex competitive neurite interactions.
  • Further experimental validation is needed to confirm tubulin as the competitive resource.