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Heterogeneous effect of two selectin gene polymorphisms on coronary artery disease risk: a meta-analysis

Zhijun Wu1, Yuqing Lou2, Lin Lu1

  • 1Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Plos One
|February 6, 2014
PubMed

Insights

The E-selectin Ser128Arg polymorphism increases coronary artery disease (CAD) risk, particularly in Asians. The P-selectin Thr715Pro polymorphism may offer protection against myocardial infarction (MI).

Area of Science:

  • Genetics and Cardiovascular Disease
  • Molecular Biology and Inflammation

Background:

  • Selectins are key mediators in the inflammatory pathways implicated in coronary artery disease (CAD) and myocardial infarction (MI).
  • Prior research on the association between selectin gene polymorphisms and CAD has yielded inconsistent findings.
  • The E-selectin Ser128Arg and P-selectin Thr715Pro polymorphisms have been extensively studied with ambiguous results.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis to clarify the association between E-selectin Ser128Arg and P-selectin Thr715Pro polymorphisms and CAD risk.
  • To investigate the potential role of these polymorphisms in myocardial infarction (MI).

Main Methods:

  • A systematic literature search was performed across multiple databases up to October 2013.
  • Meta-analysis utilized a random-effects model to calculate combined odds ratios for 10 studies on Ser128Arg (3369 cases, 2577 controls) and 10 studies on Thr715Pro (5886 cases, 18345 controls).
  • Analyses addressed between-study heterogeneity and publication bias.

Main Results:

  • The E-selectin 128Arg allele was associated with a significantly increased risk of CAD (OR=1.33).
  • Subgroup analysis revealed a significant CAD risk increase among Asians (OR=2.07) but not Caucasians.
  • The P-selectin 715Pro allele showed a significant protective association with MI (OR=0.81).
  • Publication bias was detected for the Ser128Arg polymorphism.

Conclusions:

  • The E-selectin Ser128Arg polymorphism is linked to an elevated risk of coronary artery disease.
  • The P-selectin Thr715Pro polymorphism may act as a protective factor against myocardial infarction.
Abstract

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