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Human chorionic gonadotropin expression in lung, breast, and renal carcinomas
C A Kuida1, G D Braunstein, P Shintaku
1Department of Medicine, Cedars-Sinai Medical Center-UCLA School of Medicine 90048.
Archives of Pathology & Laboratory Medicine
|March 1, 1988
Summary
This study investigated human chorionic gonadotropin (hCG) in nontrophoblastic tumors. hCG was detected in lung and breast cancer tissues, but not renal cell carcinoma, with varying frequencies.
Area of Science:
- Oncology
- Immunohistochemistry
- Biomarkers
Background:
- Conflicting reports exist on human chorionic gonadotropin (hCG) presence in nontrophoblastic tumors.
- Immunoperoxidase techniques have yielded varied results in detecting hCG.
Purpose of the Study:
- To evaluate the presence of immunoreactive hCG in lung, breast, and renal cell carcinomas.
- To compare detection rates with previous studies and discuss discrepancies.
Main Methods:
- Avidin-biotin-horseradish peroxidase method used for hCG detection.
- Analysis of 11 lung carcinomas, 10 breast carcinomas, and 10 renal cell carcinomas.
Main Results:
- hCG detected in 36% of lung carcinoma tissues.
- hCG detected in 10% of breast carcinoma tissues.
- hCG not detected in any renal cell carcinoma tissues.
Conclusions:
- Detection rates for hCG in nontrophoblastic tumors are lower than some earlier reports.
- Findings align with more recent studies, suggesting a need to reconcile discrepancies.