Related Experiment Video
Updated: May 3, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Complications in premature labor between severe preeclampsia and normal pregnancies
Zahra Fardiazar1, Mitra Ramin1, Elahe Olad Saheb Madarek1
1Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
Infants born to mothers with severe preeclampsia and premature labor face higher complication and mortality rates. This is due to the stressful conditions severe preeclampsia creates for the fetus.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Perinatal Research
Background:
- Severe preeclampsia poses significant risks, including organ failure and neurological abnormalities.
- Premature labor necessitates careful monitoring of neonatal outcomes.
- Understanding the impact of severe preeclampsia on premature infants is crucial for improving care.
Purpose of the Study:
- To compare infant complications in premature labor between severe preeclampsia and normal pregnancies.
- To investigate neonatal outcomes in relation to maternal preeclampsia status.
- To identify specific risks associated with severe preeclampsia in premature deliveries.
Main Methods:
- An analytical-descriptive study comparing 100 cases of severe preeclampsia with premature delivery to 100 cases of premature delivery without preeclampsia.
- Neonatal fate was studied, considering gestational age, delivery type, neonate features, and complications.
- Subjects were categorized into five gestational age groups (27-36 weeks).
Main Results:
- Mothers in the severe preeclampsia group were older (mean age 30.56) than the normal delivery group (mean age 27.28).
- A statistically significant difference in systolic blood pressure was observed between the groups (p < 0.001).
- No significant difference in fetal age at delivery was found between the two groups (p = 0.456).
Conclusions:
- Neonatal complications and mortality are elevated in cases of severe preeclampsia with premature labor.
- The stressful intrauterine environment associated with severe preeclampsia contributes to adverse neonatal outcomes.
- Further research is warranted to mitigate these risks and improve neonatal survival rates.
Abstract:
Severe Preeclampsia may lead to liver and renal failure, Disseminated Intravascular Coagulopathy (DIC) and Central Nervous System (CNS) abnormalities. This study aimed at comparing of infant complication in premature labor between severe preeclampsia and normal pregnancies. In this analytical-descriptive study, one hundred pregnant with severe preeclampsia and premature delivery due to severity of preeclampsia were compared with one hundred cases of premature delivery without preeclampsia to study neonatal fate. The understudy subjects were divided into five age groups of 27-28, 29-30, 31-32, 33-34, 35-36 weeks considering type of delivery, neonate features and neonatal complications related to premature delivery. Mean age of mothers of normal delivery group was 27.28 +/- 5.42 mean age of mothers of the second group was 30.56 +/- 5.86. There was statistically meaningful difference between two groups of delivery regarding patients' systolic blood pressure (p < 0.001). The study made it clear that there was not statistically meaningful difference between two groups of delivery regarding fetus age (in weeks) at the time of delivery (p = 0.456). According to findings of this study, neonatal complications and mortality is high in preeclampsia due to stressful conditions created for the fetus.
Related Concept Videos
Mitral Valve Prolapse III: Nursing Management
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Teratogenicity
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Diabetes Mellitus: Type 2 and Gestational
Measurement of Blood Pressure

