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Related Experiment Video

Updated: May 3, 2026

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
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The KIR3DS1*0130105 allele identified using high-resolution sequence-based typing.

L-M Yindom1, L Wang, T Dong

  • 1Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Tissue Antigens
|February 7, 2014
PubMed
Summary

The KIR3DS1*0130105 allele is distinguished from KIR3DS1*0130101 by a single nucleotide polymorphism in intron 5. This genetic variation may impact KIR3DS1 gene function and immune response.

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Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Human Genetics

Background:

  • Killer cell immunoglobulin-like receptors (KIRs) play a crucial role in immune regulation.
  • Specific KIR alleles, such as KIR3DS1, are associated with various immune responses and disease susceptibilities.
  • Understanding KIR allele variations is essential for personalized medicine and disease research.

Purpose of the Study:

  • To identify and characterize genetic differences between KIR3DS1*0130105 and KIR3DS1*0130101 alleles.
  • To pinpoint the specific mutation distinguishing these two KIR3DS1 variants.

Main Methods:

  • DNA sequencing of the KIR3DS1 gene.
  • Bioinformatic analysis to compare allele sequences.
  • Identification of single nucleotide polymorphisms (SNPs) and their locations.
Keywords:
AsiaKIR3DS1new allelesequence-based typing

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Main Results:

  • The KIR3DS1*0130105 allele differs from KIR3DS1*0130101 by a single G>T mutation at position 6739 in intron 5.
  • This mutation represents a specific genetic marker differentiating the two alleles.

Conclusions:

  • The identified mutation provides a precise molecular basis for distinguishing KIR3DS1*0130105 and KIR3DS1*0130101.
  • This finding contributes to the detailed cataloging of KIR gene polymorphisms.
  • Further research can explore the functional implications of this intronic mutation on KIR3DS1 expression or function.