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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Dermacozines H-J isolated from a deep-sea strain of Dermacoccus abyssi from Mariana Trench sediments
Marcell Wagner1, Wael M Abdel-Mageed, Rainer Ebel
1Mikrobiologisches Institut, Universität Tübingen , Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Abstract:
Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of 1D and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 μM.
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