[The fundus autofluorescence of the multiple evanescent white dot syndrome]

To observe the imaging features of fundus autofluorescence (FAF) in patients with multiple evanescent white dot syndrome (MEWDS).

Retrospective case-series study. Eight cases of MEWDS patients visited Xingtai eye hospital between January 2009 and December 2010 were included in this study. Three males and 5 females, aged from 19 to 48 years, mean age was 33 years old. The span between onset and visit to the hospital was between 2 to 12 days, the average time was 6.5 days. All the patients underwent comprehensive ophthalmic examination and fundus color photography, FAF, fluorescein angiography (FFA) , indocyanine green angiography (ICGA) by HRA-2. Two different spectrums of autofluorescence excited by laser of 488 nm and 787 nm were recorded, which were related to lipofuscin and melanin respectively. Dynamic imaging changes in different stages were observed and compared. The autofluorescence of fundus with white dot was paid extra attention.

The white dots in 8 eyes showed strong autofluorescence with a vague boundary in the FAF image excited by laser of 488 nm but normal autofluorescence under the FAF787 nm. The strong autofluorescence of 488 nm agreed with the white dots in the fundus photograph, hyperfluorescence lesions in FFA and the hypofluorescence focus in the later stage of ICGA. After the disease cured, the hyperfluorescence lesions in FFA also faded.

The fundus autofluorescence features of patients with MEWDS are hyperfluorescence in the site of white dots in FAF488 nm.It is the characteristic change of this disease.