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Related Concept Videos

Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Basophils and skin disorders.

Francesco Borriello1, Francescopaolo Granata1, Gianni Marone1

  • 1Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Naples, Italy.

The Journal of Investigative Dermatology
|February 7, 2014
PubMed
Summary
This summary is machine-generated.

Basophils, once thought to have limited immune function, are now recognized for their significant roles in skin disorders. Recent research highlights their involvement in various skin conditions and allergic inflammation.

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Basophils were historically considered circulating granulocytes with minimal immune function.
  • Recent advancements in research tools have enabled in vivo functional analysis of basophils.
  • Emerging evidence suggests basophils play crucial roles in various physiological and pathological processes.

Purpose of the Study:

  • To review critical advances in understanding basophil biology.
  • To discuss the roles of basophils in the pathophysiology of skin disorders.
  • To highlight the implications of basophil infiltration in skin lesions.

Main Methods:

  • Review of recent scientific literature and research findings.
  • Analysis of in vivo functional studies in mouse models.
  • Examination of human clinical data on skin lesions and basophil infiltration.

Main Results:

  • Basophils infiltrate various human skin lesions.
  • Basophils are implicated in the pathogenesis of chronic idiopathic urticaria and systemic lupus erythematosus.
  • In mouse models, basophils mediate IgE-driven skin inflammation and offer protection against tick infestation.

Conclusions:

  • Basophils possess previously unrecognized immune functions, particularly in skin immunity.
  • Understanding basophil roles is crucial for developing novel therapeutic strategies for skin diseases.
  • Further research into basophil biology will illuminate their complex contributions to health and disease.