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Updated: May 3, 2026

Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
Innate immunity cell activation in virologically suppressed HIV-infected maraviroc-treated patients
Chiara Dentone1, Antonio Di Biagio, Alessia Parodi
1aInfectious Diseases Department, Sanremo Hospital, Sanremo bCenter of Excellence for Biomedical Research (CEBR), University of Genoa cInfectious Diseases Department, IRCCS San Martino Hospital dDIMES Department of Experimental Medicine eDepartment of Informatics, Bioengineering, Robotic and System Engineering (DIBRIS) fSection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa gInfectious Diseases Department, Galliera Hospital, Genoa hInfectious Diseases Department, SS. Antonio, Biagio, Cesare Arrigo Hospital, Alessandria iInfectious Diseases Department, Amedeo di Savoia Hospital, Turin jDISSAL kDepartment of Internal Medicine (DIMI), University of Genoa, Genoa, Italy.
Abstract:
This is a cross-sectional, case-control study analyzing the effect of antiretroviral therapy (ART) including or not maraviroc, on circulating monocytes and natural killer cells. Sixty-eight HIV-positive patients virologically suppressed receiving ART at least 6 months were subdivided as receiving (group 1) or not (group 2) maraviroc in their ART. Frequency of monocytes and natural killer cells, as well as their activation markers, were studied. Modulation of innate immune cells may be differently affected by combined ART.
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