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Related Experiment Video

Updated: May 3, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
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Published on: December 23, 2022

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PFO closure: rational, procedure and devices.

R Reiter1, S G Bertog, L Vaskelyte

  • 1The University of Minnesota Medical School Minneapolis, MN, USA - horstsievertmd@aol.com.

Minerva Cardioangiologica
|February 7, 2014
PubMed
Summary
This summary is machine-generated.

Patent foramen ovale (PFO) allows particles to enter arterial circulation, potentially causing stroke. Device closure is increasingly used, with recent randomized trials comparing it to medical therapy for cryptogenic stroke patients.

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Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Patent foramen ovale (PFO) is a common heart defect present in 20-25% of people.
  • PFO can allow blood clots or other substances to travel from venous to arterial circulation, bypassing the lungs.
  • This bypass is linked to cryptogenic stroke, migraines, and decompression sickness.

Purpose of the Study:

  • To review current data on patent foramen ovale closure.
  • To discuss results from recent randomized controlled trials comparing device closure with medical therapy for cryptogenic stroke.
  • To examine PFO closure techniques, devices, and associated complications.

Main Methods:

  • Review of existing literature on PFO closure.
  • Analysis of data from three randomized controlled trials (RCTs).
  • Focus on device closure versus medical therapy in cryptogenic stroke patients.

Main Results:

  • Discusses increasing trends in PFO device closure procedures.
  • Highlights the significance of recent RCTs in evaluating PFO closure efficacy.
  • Covers implantation techniques, complications, and device variations.

Conclusions:

  • PFO closure therapy is becoming more established, supported by recent RCT data.
  • The review provides insights into the procedural aspects and outcomes of PFO closure.
  • Understanding PFO's role in various conditions and its treatment options is crucial.