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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

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Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
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Negative and Cognitive Symptoms of Schizophrenia01:30

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Related Experiment Video

Updated: May 3, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Brain networks in schizophrenia.

Martijn P van den Heuvel1, Alex Fornito

  • 1Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, Utrecht, PO Box 85500, The Netherlands, m.p.vandenheuvel@umcutrecht.nl.

Neuropsychology Review
|February 7, 2014
PubMed
Summary

Schizophrenia may stem from abnormal brain connectivity. Connectomics, using advanced neuroimaging and network science, reveals how disruptions in the brain

Area of Science:

  • Neuroscience
  • Psychiatry
  • Network Science

Background:

  • Schizophrenia is a psychiatric disorder linked to abnormal neural connectivity.
  • In vivo neuroimaging and connectomics offer new ways to study brain wiring.

Purpose of the Study:

  • To review recent findings on connectomic studies in schizophrenia.
  • To explore the relationship between schizophrenia and disruptions in brain connectivity.

Main Methods:

  • Utilizing high-field structural and functional neuroimaging techniques.
  • Applying network science and graph theory to analyze neural connectivity maps.
  • Reconstructing macroscopic neural wiring systems (connectomes).

Main Results:

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  • Connectomic studies reveal disruptions in brain connectivity in schizophrenia.
  • Abnormal structural and functional connectivity are implicated in the disorder.
  • The brain's integrative processes may be decoupled due to these disruptions.

    • Conclusions:

    • Connectomics provides a novel platform for understanding schizophrenia.
    • Abnormal brain network wiring and dynamics are central to schizophrenia.
    • Further research using connectomics can deepen our understanding of this condition.