Migraine and epilepsy in the pediatric population
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Updated: May 3, 2026

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Published on: September 20, 2024
Christopher B Oakley1, Eric H Kossoff
1Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Suite 2158, Baltimore, MD, 21287, USA, coakley1@jhmi.edu.
Insights
Childhood epilepsy and migraine share symptoms, complicating diagnosis. Differentiating these neurological conditions in children requires careful history and testing, followed by targeted treatments.
Area of Science:
- Pediatric Neurology
- Neuroscience
- Clinical Neurology
Background:
- Childhood epilepsy and migraine are prevalent neurological disorders in children.
- Similarities between epilepsy and migraine, and shared predisposing conditions, can complicate diagnosis.
- Differentiating these conditions is crucial for effective management.
Purpose of the Study:
- To review the epidemiology of childhood epilepsy and headache.
- To explore the association between epilepsy and migraine in pediatric populations.
- To outline methods for differentiating epilepsy from migraine and discuss treatment strategies.
Main Methods:
- Literature review focusing on epidemiology, clinical presentation, and diagnostic approaches.
- Analysis of shared risk factors and overlapping symptomatology.
- Discussion of current treatment modalities for pediatric epilepsy and migraine.
Main Results:
- Epilepsy and migraine present diagnostic challenges due to overlapping features.
- A thorough medical history and appropriate ancillary tests are key to accurate differentiation.
- Treatment strategies differ for acute episodes but may overlap for preventative care.
Conclusions:
- Accurate differentiation of childhood epilepsy and migraine is achievable through detailed clinical evaluation.
- Effective management requires condition-specific acute treatments and potentially overlapping preventative strategies.
- Understanding the relationship between these conditions improves patient outcomes.
Abstract:
Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology. What complicates matters is that there can be marked similarities between migraine and epilepsy as well as a variety of underlying conditions that predispose children to both seizures and headache. Thus, separating epilepsy from migraine may not be easy, but can be done with a detailed history as well as timely use of ancillary testing. Once children have been diagnosed with epilepsy, migraine, or both, treatment options become essential in attempts to manage these common, yet often disabling, neurological conditions. Acute interventions tend to be condition specific while preventative options may overlap for migraine and epilepsy. In the following review, we will discuss the epidemiology of childhood epilepsy and headache, the association between them, as well as how to differentiate epilepsy from migraine. Treatment strategies will follow before concluding with a discussion on prognosis.
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