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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

143
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
143
Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Burn Injuries01:22

Burn Injuries

4.4K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.4K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.5K
Atypical Pneumonia01:14

Atypical Pneumonia

84
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
84

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Updated: May 3, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Cutaneous blastomycosis masquerading as pyoderma gangrenosum.

Marwan M Azar1, Ryan F Relich, Bryan H Schmitt

  • 1Indiana University School of Medicine, Internal Medicine Residency Program, Indiana University, Indianapolis, Indiana, USA.

Journal of Clinical Microbiology
|February 7, 2014
PubMed
Summary

Cutaneous blastomycosis can mimic pyoderma gangrenosum, leading to misdiagnosis. Delayed treatment due to misdiagnosis can cause disseminated disease and acute respiratory distress syndrome (ARDS).

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Last Updated: May 3, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Cutaneous blastomycosis presents with diverse skin lesions.
  • Histopathologic overlap exists between cutaneous blastomycosis and pyoderma gangrenosum.
  • Accurate diagnosis is crucial for appropriate treatment.

Observation:

  • A case of cutaneous blastomycosis was initially misdiagnosed as pyoderma gangrenosum.
  • The patient received systemic corticosteroid therapy for the presumed pyoderma gangrenosum.
  • This led to the progression of the fungal infection.

Findings:

  • The misdiagnosis resulted in disseminated blastomycosis.
  • Disseminated disease progressed to acute respiratory distress syndrome (ARDS).
  • Steroid treatment exacerbated the underlying fungal infection.

Implications:

  • Highlights the importance of considering fungal infections in differential diagnoses of ulcerative skin lesions.
  • Emphasizes the potential dangers of immunosuppression in undiagnosed blastomycosis.
  • Underscores the need for advanced diagnostic techniques to differentiate similar dermatologic conditions.