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The development of Moyamoya syndrome after proton beam therapy

Nathan T Zwagerman1, Kimberly Foster, Regina Jakacki

  • 1Department of Neurological Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Pediatric Blood & Cancer
|February 7, 2014
PubMed

Insights

Radiation-induced Moyamoya syndrome (MMS) can occur after proton beam therapy in children. This case highlights a rare instance of MMS developing post-proton therapy for pediatric tumors.

Area of Science:

  • Pediatric Oncology
  • Radiation Oncology
  • Neurology

Background:

  • Moyamoya syndrome (MMS) is a known complication following cranial irradiation for pediatric tumors.
  • Existing literature primarily documents MMS after conventional photon radiotherapy.

Observation:

  • A 2-year-old child treated with proton beam therapy for a pediatric tumor developed MMS.
  • The patient's clinical presentation and diagnostic findings were consistent with radiation-induced MMS.

Findings:

  • This case represents a rare occurrence of Moyamoya syndrome developing after proton beam radiotherapy.
  • The findings suggest that proton beam therapy, like photon therapy, may pose a risk for MMS development.

Implications:

  • Further research is needed to understand the specific risks and mechanisms of MMS following proton beam therapy.
  • This case underscores the importance of long-term neurovascular surveillance in pediatric patients treated with proton beam radiotherapy.
Keywords:
moyamoyapial synangiosisproton beamradiotherapy

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