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Shock due to amlodipine overdose

Vimal Upreti1, V R Ratheesh2, Pawan Dhull3

  • 1Department of Endocrinology, Command Hospital (Air Force), Bangalore, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|February 7, 2014
PubMed

Insights

Amlodipine overdose can cause severe hypotension and shock. Prompt supportive care and high-dose calcium infusion are effective treatments for amlodipine toxicity.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Toxicology

Background:

  • Amlodipine is a widely used calcium channel blocker for hypertension and angina.
  • Amlodipine toxicity is a significant cause of cardiovascular drug overdoses.
  • Overdoses can result in life-threatening hypotension and shock.

Observation:

  • A case of severe amlodipine overdose presented with profound hypotension.
  • The patient required aggressive supportive management.

Findings:

  • High-dose intravenous calcium infusion was administered to counteract the calcium channel blockade.
  • The patient's hypotension and shock were successfully reversed with this intervention.

Implications:

  • This case highlights the critical role of early and aggressive supportive care in amlodipine overdose.
  • Intravenous calcium infusion is a key therapeutic strategy for managing amlodipine toxicity.
  • Effective management can lead to favorable outcomes in severe amlodipine poisoning.

Keywords:
Amlodipinecalcium channel blockerhypotension

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