Related Experiment Video
Updated: May 3, 2026

14:10
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
Published on: July 29, 2022
5.0K
Salmonella typhimurium meningitis in infancy
Ranjeeta Adhikary1, Sangeeta Joshi1, Meera Ramakrishnan2
1Department of Microbiology, Manipal Hospital, Bangalore, India.
Summary
A rare case of Salmonella typhimurium meningitis in an infant highlights the severity of this infection. Despite initial improvement, the infant tragically succumbed to nosocomial pneumonia, underscoring infection risks.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Meningitis is a serious infection of the membranes surrounding the brain and spinal cord.
- Salmonella typhimurium is a common cause of gastroenteritis but rarely causes meningitis in infants.
Observation:
- A four-month-old infant presented with fever, cold symptoms, and generalized convulsions.
- Clinical examination revealed fever and seizures; the anterior fontanelle was not bulging.
Findings:
- Cerebrospinal fluid analysis confirmed Salmonella typhimurium as the causative agent of meningitis.
- The infant showed initial clinical improvement with treatment.
Implications:
- This case emphasizes the importance of considering Salmonella typhimurium in infant meningitis, even if uncommon.
- The fatal outcome due to nosocomial pneumonia highlights the vulnerability of infants with serious infections and the risks of hospital-acquired infections.
Related Concept Videos
Bacterial Meningitis I: Introduction
15
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Viral Meningitis
199
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
199
Reservoir of Infection
89
Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
89
Bacterial Meningitis II: Pathophysiology
24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Development of Immunocompetence
1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Encephalitis l: Introduction
15
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
15

