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Updated: May 3, 2026
A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
Published on: March 13, 2026
Preliminary study with SprayShield™ Adhesion Barrier System in the prevention of abdominal adhesions
Tomasz Banasiewicz1, Karolina Horbacka2, Jacek Karoń2
1Department of General Surgery, Gastroenterological Oncological Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland.
Insights
SprayShield™ showed potential in reducing post-operative adhesions and simplifying ileostomy closure in a small study. Further research is needed to confirm its effectiveness in preventing peritoneal adhesions.
Area of Science:
- Surgical innovation
- Biomaterials in surgery
- Gastrointestinal surgery
Background:
- Peritoneal adhesions are challenging fibrotic bands forming post-surgery.
- Adhesions can cause significant clinical complications.
Purpose of the Study:
- To evaluate the SprayShield™ Adhesion Barrier System for reducing post-operative adhesions.
- Assessing the safety and ease of application of SprayShield™.
Main Methods:
- Prospective, multi-center, randomized, single-blind study.
- 11 subjects with ulcerative colitis or familial adenomatous polyposis.
- SprayShield™ applied to peritoneal incision and ileostomy sites.
Main Results:
- Slightly shorter ileal loop mobilization time in the SprayShield™ group.
- Lower incidence and severity of adhesions observed with SprayShield™ compared to controls.
- SprayShield™ demonstrated good adherence and conformity.
Conclusions:
- SprayShield™ is easy, safe, and quick to apply.
- Preliminary results suggest reduced adhesion formation.
- Limited patient numbers necessitate further studies to confirm efficacy.
Introduction:
Peritoneal adhesions, the fibrotic bands that form between the surfaces in the peritoneal cavity following surgery, still pose a difficult clinical challenge.
Aim:
To evaluate the SprayShield™ Adhesion Barrier System (PEG ester amine solution and a buffer solution) in reducing post-operative adhesion formation.
Material And Methods:
This was a prospective, multi-center, randomized, single blind study. A total of 11 subjects diagnosed with ulcerative colitis (UC) or familial adenomatous polyposis (FAP) were randomized: 8 to the SprayShield™ arm and 3 to the control arm. SprayShield™ was applied on the viscera directly under the midline peritoneal incision and at the site of ileostomy. During the follow-up surgery, the incidence, extent, and severity of post-operative adhesion formation were evaluated, as well as the time required to mobilize the ileal loop.
Results:
In patients who received SprayShield™ the time required to mobilize the ileal loop at the ileostomy closure was slightly shorter and the incidence and severity of adhesions were somewhat lower vs. control subjects (NS).
Conclusions:
SprayShield™ was found to be easy to use, safe, and quick to apply, and performed well in adherence and conformity. The incidence and severity of adhesions were lower for SprayShield™ subjects vs. control subjects, but due to the limited number of patients there are not enough data to confirm the effectiveness of the SprayShield™ Adhesion Barrier System in prevention of adhesions.
