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Updated: May 3, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation.

Laura Russo¹, Francesca Taraballi¹, Cristina Lupo¹

¹Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.

Interface Focus

|February 7, 2014

Summary

This summary is machine-generated.

Researchers explored methods to add amine groups to hydroxyapatite granules for better bioactive molecule attachment. Combining tetraethoxyorthosilicate and (3-aminopropyl)triethoxysilane (APTES) with acid catalysis significantly increased amine surface grafting on bioceramics.

Keywords:

APTES NMR bioceramics carbonate hydroxyapatite covalent functionalization sol–gel

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Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Published on: May 14, 2019

Area of Science:

Biomaterials Science
Surface Chemistry
Bioceramics Engineering

Background:

Hydroxyapatite is a key bioceramic for bone regeneration.
Functionalization of hydroxyapatite is crucial for immobilizing bioactive molecules.
Existing methods for amine group grafting have limitations.

Purpose of the Study:

To compare different methods for functionalizing carbonate hydroxyapatite granules with amine groups.
To enhance the surface grafting of amine groups for improved bioactive molecule tethering.
To optimize the surface chemistry of bioceramics for biomedical applications.

Main Methods:

Functionalization of carbonate hydroxyapatite granules using (3-aminopropyl)triethoxysilane (APTES).
Comparison of different reaction conditions and precursor combinations.
Utilizing tetraethoxyorthosilicate (TEOS) in conjunction with APTES and acid catalysis.

Main Results:

The combined use of tetraethoxyorthosilicate and APTES with acid catalysis demonstrated a significant increase in amine surface grafting.
This method proved more effective than other tested approaches for amine functionalization.
Enhanced amine density on the hydroxyapatite surface was observed.

Conclusions:

The developed method offers an improved strategy for functionalizing hydroxyapatite bioceramics.
Increased amine group availability facilitates enhanced tethering of bioactive molecules.
This advancement holds potential for developing next-generation biomaterials for tissue engineering and regenerative medicine.