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[Impact of the multiple births on the postnatal blood count indices in premature infants]
Insights
Multiple births increase hematological risks in premature infants, with risks escalating based on gestational age at birth. This study examines blood count indices in singletons and twins born before 33 weeks gestational age.
Area of Science:
- Neonatal Hematology
- Perinatal Medicine
- Pediatric Blood Disorders
Context:
- Premature infants face unique hematological challenges.
- Multiple births may exacerbate these issues.
- Understanding these differences is crucial for optimal infant care.
Purpose:
- To investigate the impact of multiple births on blood count indices in premature infants.
- To compare hematological parameters between singleton and twin premature infants.
- To assess the influence of gestational age on these parameters.
Summary:
- This study analyzed 299 premature infants (<33 weeks gestational age), comparing singletons and twins across various gestational age groups.
- Key blood count indices including hemoglobin, hematocrit, MCV, MCHC, and reticulocytes were measured at birth and corrected ages up to 39 weeks.
- Twins, particularly those born earlier, exhibited distinct hematological profiles, including higher initial hemoglobin and hematocrit, variable reticulocyte responses, and lower MCV levels.
Impact:
- Multiple births are identified as a risk factor for hematological conditions in premature infants.
- The degree of risk is directly proportional to the duration of intrauterine stay.
- Findings inform clinical management and monitoring of blood parameters in high-risk neonatal populations.
Purpose:
To investigate the impact of the multiple births on the blood count indices in premature infants.
Material And Methods:
299 premature infants, born before 33rd gesta-tional week (GW), are investigated, divided in 2 groups according to the ges-tational age at birth (< or = 29 GW and 30-33 GW). These groups are divided addi-tionally in 2 subgroups: 1- singletons, and 2- twins. Hemoglobin (Hgb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular Hgb concentration (MCHC), peripheral reticulocytes (Ret) are examined at birth and in 27th, 30th, 33rd, 36th and 39th week corrected age (WCA).
Results:
The congenital infections are more often in group 1 of the newborns 5 29 GW. The twins 30th-33rd GW are with lower average weight and higher frequency of late blood transfusions. Comparing to singletons less mature twins are with initial higher levels of Hgb, Hct, MCV and lower levels of MCHC in 33rd and 36th WCA. They also show high-variable bone marrow answer with high levels of Ret in 30th, 33rd and 36th WCA. Initial values of Hgb, Hct are higher in more mature twins, MCHC also, but in 33rd and 39th WCA. Ret decrease permanently after elevation in 33rd WCA. The MCV levels are under the lower limit of normal in the both age groups.
Conclusions:
The multiple births are risk factor for hematological condition in premature infants but the risk is proportional to the duration of the intrauterine stay.
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