Related Experiment Video
Updated: May 3, 2026
Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
Published on: June 5, 2010
[PRP-therapy and regular physical load in complex treatment of patients with distal form of arterial occlusion]
Insights
Chronic lower extremity ischemia affects over 20% of patients in Ukraine. Optimized indirect revascularization, PRP-therapy, and exercise significantly improved outcomes, reducing amputation rates and enhancing blood flow.
Area of Science:
- Vascular Surgery
- Regenerative Medicine
- Cardiovascular Diseases
Background:
- Chronic ischemia of lower extremities tissues is a significant health issue, comprising over 20% of cardiovascular diseases in Ukraine.
- Diffuse arterial bed affection prevents direct revascularization in 40% of patients, leading to high amputation rates (60-87%).
Purpose of the Study:
- To analyze the surgical treatment outcomes for inoperable peripheral artery occlusive disease.
- To evaluate the effectiveness of optimized indirect revascularization combined with PRP-therapy and physical exercises.
Main Methods:
- Analysis of surgical treatment for 36 patients with inoperable peripheral artery occlusion.
- Application of intraoperative ultrasound duplex scanning and optimized surgical procedures in 18 patients.
- Post-operative PRP-therapy and a tailored physical exercise regimen for muscle strengthening.
Main Results:
- Successful treatment rates increased from 55.6% to 88.9%, while unsatisfactory results decreased from 44.4% to 11.1%.
- PRP-therapy and exercise increased VEGF (Vascular Endothelial Growth Factor) by 15.6% and the malleolar-brachial index by 28.9%.
- PRP-concentrate demonstrated potent activation of VEGF, improving muscle and skin metabolism and microcirculation.
Conclusions:
- Optimized indirect revascularization methods significantly improve treatment outcomes for chronic lower extremity ischemia.
- The combination of PRP-therapy and physical exercise is a promising approach to enhance healing and vascular function.
- PRP-therapy acts as a biological activator, promoting tissue regeneration and improving blood flow in ischemic tissues.
Abstract:
In a structure of the cardio-vascular system diseases in Ukraine the part of chronical ischemia of the lower extremities tissues constitutes more than 20%. Due to diffuse affection of the distal parts of arterial bed it is impossible to succeed in performance of a direct" revascularization in 40% of patients. In 60-87% of such patients a severe ischemia of the lower extremities tissues occurs, causing the necessity of their high amputation performance on the hip level. The results of surgical treatment of 36 patients, suffering inoperable types of the peripheral arteries occlusion were analyzed. In 18 patients the algorithm of intraoperative ultrasound duplex scanning was applied, surgical interventions were performed using optimized procedures. As a second stage the PRP-therapy was conducted, since the second post-operative day all the patients have had performed the elaborated complex of physical exercises, directed on the shin and hip muscles strengthening. Optimization of the lower extremities indirect revascularization methods have permitted to increase the rate of the treatment positive results from 55.6 to 88.9%, to reduce the unsatisfactory results rate--from 44.4 to 11.1%. The PRP-therapy and complex of regular physical exercises conduction have promoted the VEGF content enhancement in the blood serum by 15.6%. malleolar-brachial index--by 28.9% in the patients, suffering occlusion of femoro-popliteo-tibial segment. PRP-concentrate constitutes a potent cell biological activator of the VEGF, improves metabolism and microcirculation in muscles and cells of the skin.
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