[Dynamics of catecholamines in serum of patients with gastroduodenal ulcers complicated by hemorrhage]

Related Experiment Video

Updated: May 3, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

14.1K

V P Kryshen', M V Trofimov

    Klinichna Khirurhiia
    |February 8, 2014
    PubMed

    Insights

    Elevated catecholamines in blood serum indicate severe gastroduodenal ulcers with hemorrhage. Gastric cancer significantly increases these levels, correlating with blood loss and poor hemostasis.

    Area of Science:

    • Biochemistry
    • Gastroenterology
    • Oncology

    Background:

    • Gastroduodenal ulcers complicated by hemorrhage present significant clinical challenges.
    • Catecholamine levels may serve as biomarkers for ulcer severity and associated complications.

    Purpose of the Study:

    • To analyze the dynamics of catecholamines in patients with gastroduodenal ulcers and hemorrhage.
    • To investigate the correlation between catecholamine levels and gastric cancer in these patients.

    Main Methods:

    • Blood serum catecholamine levels were analyzed in patients with gastroduodenal ulcers and hemorrhage.
    • Correlation with blood loss severity, endoscopic hemostasis, and inducible nitric oxide synthase (iNOS) activity was assessed.

    Main Results:

    • A significant increase in catecholamines was observed in patients with gastroduodenal ulcers complicated by hemorrhage.
    • The highest catecholamine levels were found in patients with concurrent gastric cancer and hemorrhage.
    • These elevations correlated with increased blood loss, unstable endoscopic hemostasis, and high iNOS activity in the peri-ulceral mucosa.

    Conclusions:

    • Catecholamine dynamics in blood serum can aid in prognostication of gastroduodenal ulcers with hemorrhage.
    • Monitoring catecholamines may help identify patients with concurrent gastric cancer.
    • These findings support the potential for improved treatment strategies based on catecholamine levels.

    More Related Videos

    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management06:40

    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

    Published on: June 29, 2019

    6.3K
    Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research03:48

    Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research

    Published on: March 1, 2024

    1.9K

    Related Concept Videos

    Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

    Pathophysiology of Peptic Ulcer Disease: Injurious Factors

    Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
    In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
    1.6K
    Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

    Peptic Ulcer Disease III: Clinical Manifestations and Complications

    Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
    38
    Gastritis III: Clinical Manifestations and Management01:23

    Gastritis III: Clinical Manifestations and Management

    The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
    Clinical manifestations of acute gastritis
    The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
    1.9K
    Gastritis-II: Pathophysiology01:17

    Gastritis-II: Pathophysiology

    Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
    In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
    In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
    Gastritis can stem from various causes, each...
    1.9K
    Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

    Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

    Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
    1.3K
    Peptic Ulcer Disease II: Pathophysiology01:24

    Peptic Ulcer Disease II: Pathophysiology

    Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
    44