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Extramammary Paget disease successfully treated with topical imiquimod 5% and tazarotene

Laura Frances1, Jose C Pascual, Maria Leiva-Salinas

  • 1Department of Dermatology, Hospital General Universitario, Alicante, Spain.

Dermatologic Therapy
|February 8, 2014
PubMed

Extramammary Paget disease (EMPD) is an intraepithelial adenocarcinoma usually localized in areas rich in apocrine sweat glands. Surgery remains the treatment of choice for EMPD. However, several nonsurgical treatments have been also described. Around 40 cases of EMPD treated with imiquimod 5% have been published; of these, only six correspond to nonresponses. We describe a recurrent vulvar EMPD with failure to respond to topical imiquimod 5% in monotherapy but a favorable response to its association with tazarotene.

Keywords:
extrammamary Paget diseaseimiquimodtazarotene

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