Related Experiment Video
Updated: May 3, 2026
07:08
A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
18.2K
Baicalin attenuates laser-induced choroidal neovascularization
Sung Jae Yang1, Hyoung Jo, June-Gone Kim
1Department of Ophthalmology, University of Ulsan, Gangneung Asan Hospital , Gangneung , Korea .
Current Eye Research
|February 8, 2014
Summary
Baicalin effectively inhibited choroidal neovascularization (CNV) growth in a rat model. This study suggests baicalin as a potential therapeutic agent for exudative age-related macular degeneration.
Area of Science:
- Ophthalmology
- Molecular Biology
- Pharmacology
Background:
- Choroidal neovascularization (CNV) is a major cause of vision loss in age-related macular degeneration.
- Current treatments like bevacizumab target angiogenic factors but have limitations.
Purpose of the Study:
- To investigate the inhibitory effect of intravitreally-injected baicalin on laser-induced CNV in rats.
- To analyze the impact of baicalin on key angiogenic factors.
Main Methods:
- CNV was induced in Brown Norway rats via laser photocoagulation.
- Baicalin (0.1, 1, or 5 nmol) or bevacizumab was intravitreally injected.
- CNV growth, leakage, and levels of VEGF, PDGF, and MMP-2 were assessed using fluorescein angiography, choroidal flat mounts, and Western blot analysis.
Main Results:
- Baicalin significantly reduced CNV and leakage compared to controls.
- Baicalin demonstrated a dose-dependent inhibition of CNV lesion growth.
- Baicalin attenuated the upregulation of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and matrix metalloproteinase-2 (MMP-2).
Conclusions:
- Baicalin effectively suppressed laser-induced CNV formation in rats.
- Baicalin's anti-angiogenic properties suggest its potential as a therapeutic candidate for exudative age-related macular degeneration.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K